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The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties.
This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field.
The following topics are included:
- Physical properties and processes
- Thermodynamics
- Intellectual guidance
- X-ray diffraction
- Spectroscopy Microscopy
- Particle sizing
- Mechanical properties
- Vapour sorption
- Thermal analysis & Calorimetry
- Polymorph prediction
- Form selection
- Sales Rank: #3332615 in Books
- Brand: Brand: Wiley-Blackwell
- Published on: 2011-08-08
- Original language: English
- Number of items: 1
- Dimensions: 9.89" h x 1.32" w x 6.84" l, 2.25 pounds
- Binding: Hardcover
- 526 pages
- Used Book in Good Condition
From the Back Cover
The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties.
This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field.
The following topics are included:
- Physical properties and processes
- Thermodynamics
- Intellectual guidance
- X-ray diffraction
- Spectroscopy Microscopy
- Particle sizing
- Mechanical properties
- Vapour sorption
- Thermal analysis & Calorimetry
- Polymorph prediction
- Form selection
This book serves as a vital resource for professionals and postgraduate researchers in industrial pharmacy or pharmaceutical chemistry, drug development and analytical chemistry.
It is particularly relevant for pharmaceutical scientists with limited experience of solid state characterization.
About the Author
Richard A. Storey, AstraZeneca Pharmaceuticals, Macclesfield, UK
Ingvar Ymén, AstraZeneca R&D, Södertälje, Sweden
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